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Conolidine’s analgesic consequences stem from its interaction with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors within the central anxious process, conolidine modulates alternate molecular targets. A Science Advancements study discovered that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7
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On top of that, the scientists learned the ACKR3 receptor at superior amounts in key brain regions which might be also vital opioid action centers.These benefits recommend that conolidine is in a position to limit the ACKR3 receptor’s adverse regulatory Homes and free up opioid peptides, enabling them to bind into the classical opioid receptors a